There may be many other problems that I have not mentioned. such food may increase risk of malignancies. such food may increase incidence of cerebrovascular disease, such type of food may also increase generalized atherosclerosis, metabolic syndrome including obesity, diabetes mellitus, hypertension, coronary artery disease, * Artificially sweetened food and so called jink food causes problems including * Artificially sweetened food change intestinal microbiom, * The sweeteners are added to tempt the buyer, I gather from the article, the references and suggested additional reading that: 648-53.Īn important article with a treasure of references and good suggestions for additional reading. Latouche, A., et al., A competing risks analysis should report results on all cause-specific hazards and cumulative incidence functions. Fine, Practical recommendations for reporting Fine-Gray model analyses for competing risk data. Gange, Competing risk regression models for epidemiologic data. Part A, Chemistry, analysis, control, exposure & risk assessment, 2011. Huvaere, K., et al., Dietary Intake of Artificial Sweeteners by the Belgian Population. Ph Autier and P Mullie have no conflict of interest related to their comments.ġ.ĝebras, C., et al., Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort. International Prevention Research Institute (iPRI) Philippe Autier, MD, PhD, and Patrick Mulie, PhD Methodological and logical concerns should be addressed before going further in the interpretation of study results. Moreover, if the FG method is used, articles need to report all cause-specific hazards and cumulative incidence functions. When a study is about aetiology, the cause-specific HR is to be used for causal inference thinking, not subdistribution HR obtained using the FG method. This study is about aetiology (is AS intake associated with raised risk of CVD?), and not about prediction (what is the probability of being diagnosed with CVD according to AS intake?). But the FG method is not appropriate in the context of this study. Authors have used the Fine-Gray (FG) method. But methods used for competing risk analyses are not clear. These results are hardly believable.Ĥ/ Debras et al report that “Competing risks were accounted for in all analyses”. Results for CHD suggest a higher risk for the lower than for the higher consumer group. However, hazard rations (HR) for CVD are nearly equal (HR=1.19 and 1.20 in Supplement Table 1). were true, a marked epidemic of CVD should have been noticed since long among regular soda drinkers.ģ/ There is a tenfold difference in mean daily AS consumption AS consumption between the lower and higher consumers. If risk estimates between AS or aspartame and CVD reported by Debras et al. Hence compared to general populations, daily intakes of AS of subjects included in the NutriNet-Santé cohort are trivial. In the article, mean daily intakes of AS in lower and higher consumer groups were 7.5 and 77.6 mg/day, respectively. A daily intake of AS of about 318 mg for a European adult of 80 kg is common. If subjects with diabetes at the start of follow-up were excluded from analyses, subjects with incident diabetes during follow-up were part of the cohort, and there was no adjustment for incident diabetes or new use of anti-diabetic drugs during the 9-year follow-up.Ģ/ A soda can (250 mL) contains around 200 mg of aspartame. on artificial sweetener (AS) intake and cardiovascular disease (CVD) raises logical and methodological issues.ġ/ Diabetes is a strong risk factor for CVD, and subjects with abnormal glucose metabolism are generally advised to replace sugar with AS. They are accusatory and condescending, not fully thought out, and too easy to misconstrue.The observational NutriNet-Santé study of Debras et al. I don’t like my words when I listen to it. In his 2012 biography Waging Heavy Peace, Young finally recanted “Southern Man,” a full thirty-five years after LS frontman Ronnie Vant Zant’s death. People often believe Lynyrd Skynyrd to be typical, Southern Conservatives because of where they come from, but let’s keep in mind here that these guys named their band after a gym teacher who thought they were flowery hippies who needed to cut their hair. Lynyrd Skynyrd wrote “Sweet Home Alabama” as a response to “Southern Man” and as a way to show rock fans that the South was not the racist land of protracted slavery that Canadians at the time felt that it was. On his 1970 album After the Gold Rush, Neil Young wrote a song called “Southern Man,” which described the racism in the South as he saw it after visiting there.
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